Figure 3
From: Systemic bis-phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice
Effects of subcutaneous administration on Nasal Potential Difference in F508del Cftrtm1Eur mice. (a) Tracing of Nasal Potential Difference performed in a F508del Cftrtm1Eur mouse after subcutaneous administration for 28 days of NaCl 0.9% (left panel) or c407 (22.3 mg) (right panel). (b) Summary of Nasal Potential Difference changes after perfusion of Forskolin 10 µM followed by Inh-172 5 µM in low Cl− solution (∆ Inh-172) in mice treated with NaCl 0.9% (n = 7) or c407 (n = 12).
