Table 1 Nasal potential difference in F508del Cftrtm1Eur mice after nasal application of c407 or vehicle.

From: Systemic bis-phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice

VTE* (mV) (mean, SEM)

Days of administration

D0

Baseline

n = 13

D7

NaCl

n = 13

D14

c407

n = 13

D21

Wash-out

n = 12

p

D7-D0

p

D14-D7

p

D21-D14

p

D21-D0

Δ Amiloride

10.1 (1.1)

10.5 (1.1)

11.7 (0.9)

9.2 (0.7)

NS

NS

NS

NS

Δ Low Cl−

0.1 (0.4)

1.48 (0.5)

−2.1 (1)

0.7 (0.5)

NS

0.02

0.02

NS

Δ Inh-172

1.4 (0.5)

0.4 (0.4)

2.9 (0.7)

0.2 (0.05)

NS

0.02

0.01

0.02

  1. Univariate analysis by Repeated Measures ANOVA test.
  2. *VTE: Transepithelial Potential Difference.
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