Table 2 Nasal potential difference after systemic administration of c407 or its vehicle by intraperitoneal route to KO Cftrtm1Unc (KO) and F508del Cftrtm1Eur (F508Del) mice or subcutaneous route to F508del Cftrtm1Eur and their wild type (WT) littermates.
From: Systemic bis-phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice
VTE * (mV) (mean, SEM) | Intraperitoneal administration | Subcutaneous administration | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
KO | F508del | WT | F508del | |||||||||
NaCl n = 3 | c407 n = 3 | p | NaCl n = 5 | c407 n = 9 | p | NaCl n = 14 | c407 n = 9 | p | NaCl n = 7 | c407 n = 12 | p | |
ΔAmiloride | 9.4 (0.7) | 11.8 (0.8) | NS | 9.6 (2.5) | 13.8 (1.8) | NS | 3.8 (0.4) | 3.6 (0.3) | NS | 11.0 (0.9) | 10.2 (1.3) | NS |
ΔLow Cl− | 1 (0.5) | 0.4 (0.4) | NS | −0.1 (0.8) | −3.6 (0.6) | 0.007 | −6.3 (1) | −8.8 (1.8) | NS | 0.5 (0.7) | −3.4 (1) | 0.01 |
ΔLow Cl−/Forskolin | 4.1 (0.6) | 3.1 (0.8) | NS | −1.4 (0.8) | −7.0 (1.1) | 0.002 | −7.5 (1.2) | −10.8 (2.4) | NS | 0.0 (0.7) | −3.5 (1.3) | 0.03 |
ΔInh-172 | −0.2 (0.2) | ND | NS | 0.2 (0.5) | 4.4 (1) | 0.08 | 2.3 (0.7) | 4.0 (1.2) | NS | 0.5 (0.3) | 2.6 (0.6) | 0.02 |
