Figure 2 | Scientific Reports

Figure 2

From: Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release

Figure 2

Hyperexcitability is present in young C9ORF72 MNs vs CTRL MNs. Whole-cell patch clamp of iPSC-derived MNs showed that (a) membrane capacitance (Cm), (b) membrane resistance (Rm), and (c) resting membrane voltage were not significantly different between C9 and CTRL MNs at day 40 nor at day 47. Two-Way RM ANOVA: p = ns, N = 3 lines, 1–2 differentiations. (di,ei) Representative traces of evoked action potential firing. (dii,eii) Average action potential firing per 500 ms for each current step (mean ± SEM). Non-linear regression ****p = < 0.0001.

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