Figure 3
From: Laminin matrix regulates beta-cell FGFR5 expression to enhance glucose-stimulated metabolism
FGFR5 overexpression enhances levels of gene transcripts associated with glycolytic metabolism and maturity. To better understand the mechanism underlying FGFR5 induced metabolic remodeling, cell lines overexpressing R5 were examined for changes in transcript level of genes related to metabolism and maturity. βTC3 cells overexpressing mChe and R5 constructs were compared for transcript expression levels by qPCR. Transcript data is organized by: (a) FGF-associated receptors (FGFR5 (R5), FGFR1 (R1), KLB); (b) metabolic genes (GLUT2, HK1, FASN, GCK, PKM2); and (c) maturity markers (MAFA, UCN3). Bars indicate the average fold change in transcript level ± SEM; symbols represent the individual responses of n = 5 independent experiments. *, p < 0.05 using one-tailed t-test.
