Figure 7
From: Presepsin production in monocyte/macrophage-mediated phagocytosis of neutrophil extracellular traps
Schematic representation of the mechanism of presepsin production by monocytes/macrophages by NETphagocytosis. Neutrophils invoke NETs in response to infectious bacteria in blood vessels, trapping bacteria and turning them into dead cells. Phagocytosis of NETs by monocytes/macrophages results in intracellular degradation of CD14, which is expressed highly in NETs, and the production of a presepsin, which is released into the extracellular space.
