Figure 2
From: Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans
Comparison of the crystal structures of dmJMJD7 and hsJMJD7. (A) Except for the dimerization interfaces, the overall structures of dmJMJD7 and hsJMJD7 oxygenases adopt similar folds, despite only 45% sequence conservation. The core distorted DSBH fold is highlighted. (B) Views from the active sites of dmJMJD7 and hsJMJD7 showing very similar metal ion (Mn in place of Fe) coordination and co-substrate (2OG) binding modes.
