Figure 1

Transcription levels of GPX7 in different types of human cancers compared with normal tissues (Oncomine database). (a) The number of datasets with statistically significant mRNA upregulated (red) or downregulated expression (blue) of GPX7. The numbers in the colored cell represent datasets meeting the threshold (see “Material and methods”). The gene rank was analyzed by the percentile of the target gene at the top of all genes measured in each research. The cell color is determined by the best gene rank percentile for the analyses within the cell. Significant Unique Analyses indicate that the queried gene is significantly different in studies. Total Unique Analysis indicates the total number of studies that contain the queried gene. (b) GPX7 expression levels in distinct glioma cohorts. Rembrandt microarray cohort (Normal samples = 28 samples; LGG samples = 225 samples; GBM samples = 219 samples); Gravendeel microarray cohort (Normal samples = 8 samples; LGG = 117 samples; GBM = 159 samples); Kamoun microarray cohort (Normal samples = 9 samples; LGG = 154 samples; GBM = 16 samples); Chinese Glioma Genome Atlas (CGGA) RNA-seq cohort (Normal samples = 20 samples; LGG = 625 samples; GBM = 388 samples); TCGA RNA-seq cohort (LGG = 518 samples; GBM = 163 samples). Red boxplots: Tumor samples from TCGA. Grey boxplots: Normal samples from GTEx (Genotype–Tissue Expression database) (N = 207 samples). (c) mRNA expression of GPX7 in different types of cell lines of human cancer from CCLE (Cancer cell line encyclopedia). The red arrow indicates the glioma cell lines (66 cell lines). The number next to the lineage name represents the number of cell lines in the lineage. The expression ranks in gliomas using Affymetrix GeneChip data. Statistical significance is denoted by *p < 0.05, **p < 0.01, ***p < 0.001. (d) GPX7 gene expression profiling during the cell cycle in T98G cells (Human Glioblastoma Cell line) (GDS3364 from GSE8537 dataset)³⁵.