Figure 3

GPX7 expression was correlated with CNAs (Copy Number Alterations), IDH1 mutational status and 1p/19q co-deletion. (a) Heatmap integrating GPX7 expression (Log2—Norm Count + 1), CNAs (Copy Number Alterations) status (Log2—Tumor/Normal) of chromosomes 1, 7, 10 and 19, histology and WHO grade of LGG and GBM cohorts from TCGA. GPX7 mRNA expression in molecular subtypes of (b) Low-Grade Gliomas (LGG) cohort, according to WHO⁸¹ (IDH-mutant, 1p/19q codeleted; IDH-mutant, 1p/19q non-codeleted; and IDH-wildtype, 1p/19q non-codeleted group) and of (c) GBM cohort, according to Verhaak⁸² (Proneural; Classical; Mesenchymal; Neural) from TCGA database. (d) GPX7 expression correlates with IDH-1 status in CGGA gliomas. (e) GPX7 expression correlates with 1p/19q co-deletion in CGGA gliomas. *p < 0.05, **p < 0.01, ***p < 0.001.