Table 1 Mean arterial pressure, lactate, PaO2 and PaO2/FiO2 ratios. Data are reported as mean (SEM) and assessed using two-way ANOVA with Bonferroni correction. *P < 0.05 compared with control, n = 10 rats.
Group | Time point (hrs after infection) | Mean arterial pressure (mmHg) | Lactate (mmol/L) | PaO2 (mmHg) | PaO2/FiO2 |
|---|---|---|---|---|---|
Saline-injected control | 0.5–2 h | 85.3 (2.7) | 1.00 (0.12) | 106.0 (4.6) | 335 (12) |
2.5–4 h | 81.4 (1.8) | 0.84 (0.11) | 97.0 (4.9) | 324 (23) | |
4.5–6 h | 78.2 (1.9) | 0.84 (0.09) | 97.6 (2.1) | 317 (6) | |
Endpoint | N/A | 0.98 (0.13) | 99.9 (6.8) | 341 (31) | |
Feces-induced peritonitis | 0.5–2 h | 86.8 (2.6) | 1.41 (0.28) | 105.4 (6.2) | 340 (16) |
2.5–4 h | 79.3 (2.7) | 1.04 (0.15) | 94.3 (4.4) | 321 (19) | |
4.5–6 h | 60.8 (3.1)* | 1.85 (0.24)* | 91.4 (7.1) | 293 (30) | |
Endpoint | N/A | 2.75 (0.27)* | 96.9 (5.7) | 329 (27) |
