Figure 5
From: Vero cells gain renal tubule markers in low-calcium and magnesium chemically defined media
Expression regulation of cell cycle related genes. (a) KEGG cell cycle showing differentially regulated genes for the comparison of Sus_CDM2 against Adh_CDM2 rendered with Pathview. The color code determines the direction of significantly differentially regulated genes (FDR < 0.001) according to the legend at the top of the figure. A white background of a text box means that the gene was not identified as expressed. (b) LFC for the top 500 cell cycle related genes from Cyclebase 3.0 grouped to their peak expression phase. Non-periodic: no known expressional changes during the cell cycle, G1: Gap phase 1 of the cell cycle, G1/S: Gap 1 to synthesis transition phase, S: synthesis phase, G2: Gap phase 2, G2/M: Gap2 to mitosis transition phase, M: mitosis phase. (c) LFC for genes linked to positive (positive) or negative (negative) regulation of apoptosis according to gene ontology.
