Figure 3
(A, B) Thrombospondin 1 (THBS1) gene expression in participants with MINS (Red) versus no MINS (Blue) in the overall cohort (A), and in a sensitivity analysis with negative pre-operative troponin values (B). (C) Correlations between THBS1 expression and relevant GO genesets were observed in 8 pathways; scatterplots of THBS1 and GO platelet degranulation and coagulation genesets are shown in greater detail. (D) Pooled differential expression analyses of THBS1 in non-surgical patients with and without cardiovascular events over long-term follow-up in observational and case–control cohorts from the CATHGEN database (observational cohort log2-fold change 0.12, 95% CI 0.03–0.21, p = 0.049; aOR 4.93; 95% CI 1.41–17.22; p = 0.012; case–control cohort log2-fold change 0.07, 95% CI 0.01–0.13, p = 0.143; aOR 2.03; 95% CI 1.06–3.87; p = 0.032).
