Table 6 The modulation of the verapamil-stimulated (100 µM) P-glycoprotein ATPase activity by selected ketone-selenoesters.

From: Ketone-selenoesters as potential anticancer and multidrug resistance modulation agents in 2D and 3D ovarian and breast cancer in vitro models

Cpd

IC50 [µM]

K3

11.7 ± 1.0a

K4

23.0 ± 0.2b

K7

25.7 ± 0.6c

  1. Data are expressed as the average inhibitory concentration (IC50) of three repetitions with standard error of the mean (SEM). The statistical differences between compounds were calculated by one-way analysis of variance (ANOVA) and Duncan’s post hoc test (p ˂ 0.05), where significances were denoted by different letters (a–c).
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