Figure 7
Patterns of gene sets regulation in male and female kidneys throughout renal IRI in the time comparison. An example of the gene sets of selected clusters represented by hierarchical clustering. (A) Heatmap (of time comparisons) was created with the normalized enrichment score (NES) values of the gene sets calculated by GSEA analysis. The red and blue colors refer to gene sets that are over- or under-represented in the heat-maps. (B) Five prominent patterns for time comparison were determined. (C) A summary of these five temporal patterns is depicted in a diagram, where patterns displayed in each sex are illustrated by a colored arrow positioned at the time point where they are up-regulated (PR, PS, WL). PR pre-ischemia, PS post-ischemia, WL one week later.
