Table 2 Interaction effect of the moderator insulin dose and serum Mg2+ associated with HbA1c.

From: The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals

 

Crude model

Model 1

Model 2

B (95% CI)

P-value

B (95% CI)

P-value

B (95% CI)

P-value

Constant

24.95 (− 4.21; 54.10)

0.094

26.90 (− 2.38; 56.18)

0.072

24.72 (− 11.04; 60.47)

0.175

Serum Mg2+ (mmol/L)

37.88 (3.97; 71.80)

0.029

32.78 (− 0.84; 66.41)

0.056

32.66 (− 1.76; 67.08)

0.063

Insulin dose (IU/kg)

84.12 (43.82; 124.42)

 < 0.001

76.25 (36.12; 116.38)

 < 0.001

69.25 (28.43; 110.06)

0.001

Serum Mg2+ (mmol/L) * insulin dose (IU/kg)

− 86.97 (− 133.72; -40.22)

 < 0.001

− 77.08 (− 123.73; -30.43)

0.001

− 71.91 (− 119.11; -24.71)

0.003

  1. Model 1 is age- and sex adjusted. Model 2 is adjusted for duration of diabetes (years), eGFR (< 60, 60–90, > 60 mL/min/1.73m2), alcohol use (yes/no), smoking (current, former, never), SBP (mmHg), TG (mmol/L), LDL cholesterol (mmol/L), statins (yes/no) and PPI (yes/no) drugs. eGFR = estimated glomerular filtration rate, LDL = low-density lipoprotein, Mg2+ = magnesium, PPI = proton pump inhibitor, SBP = systolic blood pressure, TG = triglycerides.
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