Figure 4

Effect of plain cream, plain gel, Coriander oil cream formula, CEONLC nanoemulgel formulation, and standard cream treatment on protein expression of (A) AP-1, (B) JNK, (C) TGFβ, (D) TGFβRII, and (E) SMAD3 in skin homogenates of photoaged mice. Each result represents the mean value for 8 mice ± SD of the mean. Statistical analysis was carried out by one-way ANOVA followed by Tukey’s multiple comparison test. *Statistically significant from the normal control group at p ≤ 0.05, #statistically significant from the UV injured group at p ≤ 0.05, α statistically significant from the plain cream base group at p ≤ 0.05, and β statistically significant from the plain gel base group at p ≤ 0.05.