Figure 5 | Scientific Reports

Figure 5

From: Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis

Figure 5

Treatment effects on liver inflammation, fibrosis and lipids. Shown are changes in liver histological and biochemical markers following 12 weeks of treatment with the study drugs. (A) Change in terminal liver Col1A1. (B) Change in terminal liver Gal-3. Quantification of Col1A1 and Gal-3 was determined by histomorphometry. (C) Total liver cholesterol (TC) content. (D) Total liver triglycerides (TG). Data are expressed as mean ± SEM (n = 11–12). *p < 0.05, **p < 0.01, ****p < 0.0001 vs. vehicle control.

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