Table 2 Best fit values for ED50 (95% CI within parentheses) from the agonist vs. normalized response variable least square fit analysis performed on pooled red blood cell concentration data from transdermal iontophoresis of acetylcholine as measured by polarization spectroscopy. ED50 expressed as time (min) to 50% of the full (100%) response after each iontophoretic pulse (1–3) during iontophoresis (10 min).

From: In vivo dose–response analysis to acetylcholine: pharmacodynamic assessment by polarized reflectance spectroscopy

ED50

1% ACh

0.1% ACh

0.01% ACh

0.001% ACh

0.0001% ACh

Pulse 1

2.0 (1.5–2.4)

2.2 (1.7–2.7)

1.9 (1.4–2.4)

2.8 (1.5–4.0)

2.2 (1.3–3.1)

Pulse 2

1.2 (0.29–1.8)

1.2 (0.59–1.7)

1.3 (0.41–1.9)

1.7 (0.48–2.6)

2.1 (1.4–2.7)

Pulse 3

1.5 (1.0–1.9)

1.3 (0.93–1.6)

1.3 (0.85–1.8)

1.1 (0.19–1.9)

0.98 (0.019–1.8)

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