Table 1 Cardiac ultrasonography was carried out before MI induction (on the day of surgery) and after MI induction (1 day and 7 days later).

From: A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction

 

Baseline

Post-day1

Post-day7

Saline (n = 5)

Vaccine (n = 7)

Saline (n = 4)

Vaccine(n = 5)

Saline (n = 8)

Vaccine (n = 13)

LVAW (mm)

2.05

 ± 0.05

2.05

 ± 0.05

1.51

 ± 0.11

1.51

 ± 0.14

0.97

 ± 0.10

1.27

 ± 0.10*

LVDd (mm)

5.75

 ± 0.05

5.75

 ± 0.05

6.58

 ± 0.12

7.21

 ± 0.18*

7.83

 ± 0.23

7.14

 ± 0.31

LVDs (mm)

2.55

 ± 0.14

2.55

 ± 0.14

5.24

 ± 0.11

5.26

 ± 0.30

6.06

 ± 0.20

5.00

 ± 0.37*

EF (%)

89.8

 ± 1.3

89.7

 ± 1.4

47.4

 ± 3.4

57.8

 ± 4.6

49.5

 ± 3.2

62.0

 ± 3.9*

FS (%)

55.5

 ± 2.2

55.5

 ± 2.2

20.9

 ± 1.8

27.1

 ± 2.8

22.1

 ± 1.8

30.9

 ± 3.1*

  1. Data shows no difference between the saline and vaccine groups at baseline and on post-day1. However, vaccination prevents the deterioration of cardiac function and myocardial remodeling on post-day7.
  2. MI myocardial infarction, LVAW left ventricular anterior wall, LVDd diastolic dimension of left ventricle, LVDs systolic dimension of left ventricle, EF ratio of left ventricular ejection fraction, FS ratio of left ventricular fractional shortening.
  3. *P < 0.05. Values were compared between the saline group and the vaccine group by Student’s t-test.
Back to article page