Figure 4 | Scientific Reports

Figure 4

From: Supporting the gastrointestinal microenvironment during high-dose chemotherapy and stem cell transplantation by inhibiting IL-1 signaling with anakinra

Figure 4

Anakinra reduces mucosal barrier injury-associated dysbiosis and controls enteric pathogen expansion. Melphalan caused compositional changes in the fecal microbiota that persisted for the entire experimental period (A). MEL + ANA rats only showed significant PCoA changes at day 4 (B). Taxonomic analysis (C) showed expansion of Enterobacteriales in MEL only rats, with increases in E.Coli (D), Bacteroidetes vulgates (E) and Clostridium sp (F). Data shown as individual samples, with the exclusion of Panel C which shows mean relative abundance. N = 8/group, all analyzed longitudinally via repeated stool collection. All statistical analyses for microbiota data are outlined in supplementary methods.

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