Figure 6 | Scientific Reports

Figure 6

From: Molecular mechanisms of bifunctional vitamin D receptor agonist-histone deacetylase inhibitor hybrid molecules in triple-negative breast cancer

Figure 6

Analysis of the results of comparative RNAseq gene expression profiling studies of 4TO7 cells treated with vehicle, 1,25D, SAHA, 1,25D + SAHA and DK-406 for 6 or 48 h. (a) Venn diagrams representing overlaps in genes regulated by 1,25D, 1,25D + SAHA or SAHA alone and DK-406 in cells treated for 6 or 48 h, as indicated. (b) Analysis of the overlap between gene expression profiles in cells treated with DK-406 for 6 or 48 h with those treated with 1,25D + SAHA (left). The center and right Venn diagrams show the overlap between common genes regulated in DK-406- and 1,25D + SAHA-treated cells and genes regulated by 1,25D alone (center) or by SAHA alone (right). 1,25D or SAHA. (c) Same as in (b), except downregulated genes are shown.

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