Figure 2

Response curves of eCBome mediators and precursors (fmol/μl) to maximal aerobic test according to the diet. Panels show results for (A) N-acylethanolamines, (B) monoacylglycerols and (C) polyunsaturated fatty acids. The graph represents the mean with the standard error of the plasmatic concentrations of these lipids at each time point for the two diets. T_pre corresponds to the initial concentration before the aerobic test, T₀ corresponds to the immediate end of the aerobic test and T₁₅, T₃₀, T₄₅ and T₆₀ correspond to the recovery phase. Lipid concentrations have been normalized using ranked values fitted into mixed linear-effect models (LME) and differences between diets and times have been tested by analysis of variance (ANOVA). For difference between diets, significance was set at p < 0.1 (.), p < 0.05 (*), p < 0.01 (**) and p < 0.001 (***). For difference between times, indicated by bold blue line, significance was set at p < 0.1 (a), p < 0.05 (b), p < 0.01 (c), p < 0.001 (d). N = 7 per diet. Names of the molecules are anandamide (AEA), N-palmitoylethanolamine (PEA), N-oleoylethanolamine (OEA), N­linoleoylethanolamine (LEA), N-stearoylethanolamine (SEA), N­docosapentaenoylethanolamine (DPEA), N­eicosapentaenoylethanolamine (EPEA), N­docosahexaenoyl‑ethanolamine (DHEA), 1- plus 2-arachidonoyl-glycerol (2-AG), 1- plus 2-palmitoyl-glycerol (2-PG), 1- plus 2-oleoyl-glycerol (2-OG), linoleoyl-glycerol (2-LG), 1- plus 2-eicosapentaenoyl-glycerol (2-EPG), 1- plus 2-docosaepentaenoic-glycerol (2-DPG), 1- plus 2-docosahexaenoyl-glycerol (2-DHG), arachidonic acid (AA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA).