Figure 8
From: Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart
Cardiac gene expression in response to fasting in cmFgf21−/− mice. (A) qPCR analysis of FGF21, PPARα, mTOR, Nrf2, and catalase mRNA levels in the heart in cmFGF21−/− and FGF21fl/fl mice subjected to a 24-h fast. Data are mean ± SD (n = 5). **p < 0.01 vs control analyzed by unpaired Student’s t-test. (B) Proposed scheme for the role of βOHB and FGF21 in the regulation of oxidative stress response gene expression during fasting in the heart. Prolonged fasting increases circulating levels of βOHB and FGF21, which promote Nrf2 and its downstream oxidative response genes (Nox4, catalase, Ucp2), partly through the PGC1α/PPARα signaling pathway. In Fgf21−/− mice, such a response is induced to a greater extent by more increased levels of serum βOHB. Pathway promoted in Fgf21−/− mice is indicated by red.
