Figure 2 | Scientific Reports

Figure 2

From: Protein N-glycosylation aberrations and glycoproteomic network alterations in osteoarthritis and osteoarthritis with type 2 diabetes

Figure 2

N-glycosylated peptides and their N-glycosylation sites with differential abundance were identified in pairwise comparisons of OA, DM-OA, and normal control. (A) The number of N-glycosylated peptides identified in pairwise comparisons of OA, DM-OA, and normal control groups with the criteria of the fold change (FC) > 2 (red) or < 0.5 (blue) and P < 0.05. Dark red and dark blue indicated criteria of FC > 10 or < 0.1. (B) Volcano diagrams for each pairwise comparison drawn by logarithmically transformed change folds versus P-value. (C) Hierarchical clustering drawn by Cluster 3.0 (http://bonsai.hgc.jp/~mdehoon/software/cluster/software.htm) and Java Treeview software (http://jtreeview.sourceforge.net) based on the N-glycopeptides abundance profiles and heatmaps (Complexheatmap R Version 3.4) showing the abundances of N-glycopeptides containing N-glycosites in pairwise comparisons, while all of these groups with the criteria of the FC > 2 (red) or < 0.5 (blue) and unadjusted P < 0.05. * indicate an FDR < 0.05.

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