Figure 1

In vivo drug release from TAF implants in C57BL/6 J mice (N = 3 per timepoint) estimated via residual drug analysis in used devices. Symbols correspond to means ± SEM; solid line, simple linear regression; broken lines, 95% confidence bands. (A) Low-releasing implants; slope = 0.28 ± 0.06 mg d^-1; R² = 0.875. (B) High-releasing implants; slope = 0.58 ± 0.21 mg d^-1; R² = 0.716.