Table 2 Model describing the systemic PK parameters for TFV, using IV and SQ co-modeling.

From: Fundamental aspects of long-acting tenofovir alafenamide delivery from subdermal implants for HIV prophylaxis

Parameter

Units

Estimate

CV (%)

V

L

4.59

10.8

CL

L d-1

6.45

6.3

Vp

L

6.32

14.2

CLp

L d-1

2.94

26.0

t1/2

d

2.3

NA

F

 

0.97

12.3

Kout

d-1

2.33

26.9

Vm/Km

L d-1

1.15 × 10–5

23.4

Model error

Plasma

%

34.4

14.7

PBMC

%

82.3

10.0

  1. V, Volume of distribution of the central compartment; CL, Total body clearance; Vp, Volume of distribution of the second compartment; CLp, Clearance from the second compartment; t1/2, Elimination half-life; F, Bioavailability/exposure scaling; Ka, Absorption rate parameter; Vcell, PBMC physiological volume; Kout, Elimination rate parameter; Vm, Maximum rate achieved by the system using Michaelis–Menten kinetics; Km, Michaelis constant; multiplicative error, error that is proportional to concentration.
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