Table 5 Simulated systemic drug concentrations in C57BL/6 J mice at 6 h following oral TAF dosing over a range of oral bioavailabilities (F).
TAF dose µmol | F | Plasma [TFV] nM (ng mL-1) | PBMC [TFV-DP] nM (fmol/106 cells) |
|---|---|---|---|
1.25 | 0.1 | 0.451 (0.130) | 38.0 (7.6) |
1.25 | 0.25 | 1.13 (0.325) | 94.5 (18.7) |
2.00 | 0.1 | 0.723 (0.208) | 60.5 (12.1) |
2.00 | 0.25 | 1.82 (0.522) | 147 (29.3) |
