Figure 5 | Scientific Reports

Figure 5

From: The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels

Figure 5

Population activity before and after pitolisant treatment is accurately classified by linear support vector machine. (A) Accuracy of two-way decoders discriminating before and after treatment. Decoders based on population activity data before and after pitolisant treatment performed better, compared with saline treatment (**p = 0.0053, paired t-test). (B) Decoders constructed from single neuron data before and after pitolisant treatment performed poorer, compared with saline treatment (*p = 0.045, paired t-test). (C) Decoders constructed from population activity data without excitatory responsive neurons performed similarly between saline and pitolisant treatments (p = 0.3020, paired t-test). (D) Decoders constructed from population activity data without inhibitory responsive neurons performed similarly between saline and pitolisant treatments (p = 0.0897, paired t-test). (E) Decoders constructed from population activity data without stable neurons performed better than those treated with saline (**p = 0.0038, paired t-test). Data are reported as mean ± SEM.

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