Table 4 Primary cases with minor histological subtype and metastasis cases.

From: One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study

Primary/meta

Patient no.

Primary organ

Histological type

Lymph node station

IPD/OSNA*

CK19 mRNA (copies/μl)

Primary

3

Lung

Combined Sq and SCLC

5 (subaortic node)

Negative/negative

 < 250

11 (interlobar node)

Negative/negative

 < 250

12 (lobar node)

Negative/negative

 < 250

17

Lung

PC

9 (pulmonary ligament node)

Positive/macro

17,000

25

Lung

SCLC

7 (subcarinal node)

Negative/negative

 < 250

52

Lung

SCLC

10R (hilar node)

Negative/negative

 < 250

11 s (interlobar node)

Negative/negative

 < 250

73

Lung

AdSq

4L (lower paratracheal node)

Negative/negative

 < 250

5 (subaortic node)

Negative/negative

 < 250

6 (para-aortic node)

Negative/negative

 < 250

78

Lung

Angiosarcoma

4R (lower paratracheal node)

Negative/negative

 < 250

10R (hilar node)

Negative/negative

 < 250

Occult primary

2

Unknown

SCLC/large

4L (lower paratracheal node)

Negative/negative

 < 250

6

Unknown

SCLC

11i (interlobar node)

Positive/macro

6400

Meta

33

Kidney

RCC

6 (para-aortic node)

Positive/micro

2300

43

Retroperitoneum

Sarcoma

10R (hilar node)

Negative/negative

 < 250

69

Bone

Sarcoma

11i (interlobar node)

Negative/negative

 < 250

  1. IPD, interoperative pathological diagnosis; Meta, metastasis; Sq, squamous cell carcinoma; SCLC, small cell lung cancer; PC, pleomorphic carcinoma; AdSq, adenosquamous cell carcinoma; RCC, renal cell carcinoma.
  2. *In the OSNA assay, macro, micro, and negative showed > 5000, 250–5000, and < 250 copies/uL of CK19 mRNA, respectively.