Figure 3

Dysregulation of T-cells composition in peripheral blood of COVID-19 patients. Application of T-distributed stochastic neighbor embedding (t-SNE): clusters were named based on the cluster-specific antigen expression patterns in healthy subjects (A) and COVID-19 patients (B). Ratio between absolute counts of CD4⁺/CD8⁺ T-cells (C), CD4⁺CD45RA⁺/CD8⁺CD45RA⁺/T-cells (D) and CD4⁺CD45RO⁺/CD8⁺CD45RO⁺/T-cells (E), CD4⁺T-cells (F), CD4⁺CD45RA⁺ (G), CD4⁺CD45RO⁺ (H), CD8⁺T-cells (I), CD8⁺CD45RA⁺ (L), CD8⁺CD45RO⁺ (M) are shown. Color code: grey, healthy subjects; green, mild COVID-19; orange, moderate COVID-10, red, severe COVID-19. COVID-19 severity was defined according to qCSI, based on respiratory rate, pulse oximetry and oxygen flow rate. Stars denote significance according to ANOVA test among the three COVID groups (mild, moderate, severe), *p < 0.005, **p < 0.001.