Table 2 Univariate and multivariable logistic regression analyses of common inflammatory parameters, plasma IL-1β and gene expression of IL1B, NLRP3 and CASP1.

From: Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease

Parameter

Univariate logistic regression analysis

Multivariable logistic regression analysis

OR

95% CI

P value

OR

95% CI

P value

CRP

1.24

1.09–1.41

0.001

   

FIB

2.56

1.65–3.95

< 0.001

2.06

1.04–4.07

0.040

WBC

1.48

1.25–1.76

< 0.001

1.24

1.00–1.52

0.050

IL-1β

5.53

2.05–14.90

< 0.001

5.03

2.11–11.02

< 0.001

IL1B

2.25

1.25–4.05

0.007

   

NLRP3

4.81

2.40–9.26

< 0.001

   

CASP1

3.21

1.93–5.34

< 0.001

   
  1. Significant values are in bold.
  2. CRP C-reactive protein, FIB fibrinogen, WBC white blood cells, IL-1β interleukin-1beta, IL1B interleukin-1beta gene, NLRP3 nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 gene, CASP1 caspase-1 gene, OR odds ratio, CI confidence interval.
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