Table 1 Baseline demographic characteristics of patients according to neurological outcomes at hospital discharge.

From: Artificial neural network-boosted Cardiac Arrest Survival Post-Resuscitation In-hospital (CASPRI) score accurately predicts outcome in cardiac arrest patients treated with targeted temperature management

Variables

Whole cohort (n = 570)

Favorable outcome (n = 117)

Unfavorable outcome (n = 453)

p-value

OR (95% CI)

Age (years)a

64.6 ± 15.9

58.1 ± 16.6

66.3 ± 15.3

< 0.0001

1.03 (1.02–1.05)b

Female, n (%)

194 (34.0)

30 (25.6)

164 (36.2)

0.037

0.61 (0.38–0.96)

Initial cardiac arrest rhythm, n (%)a

   

< 0.0001

 

VF/Pulseless VT

209 (36.7)

79 (67.5)

130 (28.7)

  

Pulseless electrical activity

137 (24.0)

30 (26.6)

107 (23.6)

  

Asystole

224 (39.3)

8 (6.8)

216 (47.7)

  

Pre-arrest CPC scorea

1.29 ± 0.60

1.04 ± 0.20

1.36 ± 0.65

< 0.0001

6.46 (2.7–15.4)b

Arrest location, n (%)a

     

OHCA

463 (81.2)

97 (82.9)

366 (80.8)

0.691

1.15 (0.68–1.97)

IHCA

107 (18.8)

20 (17.1)

87 (19.2)

0.250

 

 Telemetry unit

57 (10.0)

14 (12.0)

43 (9.5)

  

 Intensive care unit

9 (1.6)

1 (0.9)

8 (1.8)

  

 Non-monitored unit

41 (7.2)

5 (4.3)

36 (8.0)

  

Duration of resuscitation (min)a

24.0 ± 17.7

21.5 ± 21.0

24.7 ± 16.7

0.132

1.01 (1.0–1.02)b

MAP at ROSC (mmHg)a

94.6 ± 31.0

104.3 ± 29.8

92.2 ± 30.8

0.0001

0.99 (0.98–0.99)b

Comorbidities, n (%)

Renal insufficiencya

144 (25.3)

18 (15.4)

126 (27.8)

0.006

0.47 (0.27–0.81)

Hepatic insufficiencya

18 (3.2)

1 (0.9)

17 (3.8)

0.142

0.22 (0.03–1.68)

Sepsisa

59 (10.4)

3 (2.6)

56 (12.4)

0.001

0.19 (0.06–0.61)

Malignancya

72 (12.6)

7 (6.0)

65 (14.3)

0.013

0.38 (0.17–0.85)

Diabetes mellitus

236 (41.4)

33 (28.2)

203 (44.8)

0.001

0.48 (0.31–0.75)

Hypertension

322 (56.5)

62 (53.0)

260 (57.4)

0.404

0.84 (0.56–1.26)

Coronary artery disease

152 (26.7)

30 (25.6)

122 (26.9)

0.816

0.94 (0.59–1.49)

Heart failure

109 (19.1)

17 (14.5)

92 (20.3)

0.187

0.66 (0.38–1.17)

Arrhythmia

71 (12.5)

16 (13.7)

55 (12.1)

0.640

1.15 (0.63–2.08)

COPD or asthma

62 (10.9)

6 (5.1)

56 (12.4)

0.029

0.38 (0.16–0.91)

Previous cerebral vascular disease

74 (13.0)

6 (5.1)

68 (15.0)

0.003

0.31 (0.13–0.72)

CASPRI score

17.8 ± 5.6

13.2 ± 3.8

18.9 ± 5.5

< 0.0001

1.28 (1.21–1.36)b

  1. CASPRI Cardiac Arrest Survival Postresuscitation In-hospital, CI confidence interval, COPD chronic obstructive pulmonary disease, CPC cerebral performance category, IHCA in-hospital cardiac arrest, MAP mean arterial pressure, OHCA out-of-hospital cardiac arrest, OR odds ratio, ROSC return of spontaneous circulation, VF ventricular fibrillation, VT ventricular tachycardia.
  2. aVariables used to calculate CASPRI score.
  3. bOdds ratio of per unit changes.
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