Figure 2
From: Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
Treatment of mice with obesogenic diets supplemented with myriocin containing Cordyceps extracts reduces ceramide without altering intestinal morphology. Quantitative mass-spectrometry analyses of (A) Dihydroceramide, (B) Ceramide (C) Dihydro-sphingomyelin (dhSM), (D) Sphingomyelin, (E) Glucosylceramide and (F) Diacylglycerol content in serum isolated from C57Bl6/J fed high fat diets supplemented with starch (control), Sample 1 and sample 6 for 4-weeks and 12-weeks (N = 5 per group). (G) Following 12-weeks of dietary Cordyceps intervention small intestine was assessed histologically (H&E staining; N = 3 animals per group) and representative samples are shown. Values are expressed as mean ± SEM, *p < 0.05, **p < 0.001, ***p < 0.0001 vs control.
