Figure 5
From: Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
Cordyceps enriched in myriocin increases insulin sensitivity, resolves hepatic steatosis. C57Bl6/J mice fed high fat diets supplemented with starch (control), Sample 1 and Sample 6 for 12-weeks. (A) Fed blood glucose levels were determined every 3-weeks until the end of the study. (B) Fasted blood glucose levels were determined following 10-weeks of dietary intervention. (C) Glucose and (D) Insulin tolerance tests were performed following 4-weeks of dietary intervention (N = 5–7 animals per group). Following euthanasia, (E) liver pAKT (s473) and AKT was determined by Western Blotting (N = 3 animals per group), (F) livers were evaluated histologically (H&E staining; N = 3–4 animals per group) and (G) liver triglyceride content was determined by mass-spectrometry (N = 5 animals per group). Values are expressed as mean ± SEM, *p < 0.05, **p < 0.001, ***p < 0.0001 vs control.
