Figure 1
From: Altered epithelial barrier functions in the colon of patients with spina bifida
Rectal adaptation to isobaric distension. (A) Increasing the pressure of distension increased the recorded initial rectal volume (pressure effect, p < 0.0001). Compared with the HVs, the recorded initial rectal volumes (rectal compliance) were significantly lower in the patients with SB (group effect, p = 0.01; interaction group pression, p = 0.04). (B) Increasing the pressure of distension increased the recorded maximal rectal volumes (pressure effect, p < 0.0001). (C) Increasing pressure of distension decreased the rectal tone (maximal volume–initial volume) up to the treshold of 21 mmHg (pressure effect, p < 0.0001) for both groups. Compared with the HVs, rectal tone was significantly higher in the patients with SB up to the treshold of 21 mmHg (group effect, p = 0.08; interaction group pression; p = 0.001). *Patients with Spina Bifida; O Healthy volunteers.
