Table 1 Baseline characteristics of the 326 patients.

From: Shorter pruritus period and milder disease stage are associated with response to nalfurafine hydrochloride in patients with chronic liver disease

Factor

 

Gender (male/female)

164/162

Age (years)

71 (18–93)

Height (cm)

158 (133–176)

Body weight (kg)

57.2 (29.0–102.5)

Itching period (months)

4.0 (0.25–120)

HCV/PBC/Alc/NASH/HBV/AIH/Overlap/Others

114/62/47/41/21/11/6/24

Child–Pugh classification A/B/C

192/84/50

Hepatocellular carcinoma (presence/absence)

60/266

Ascites (none/mild/moderate)

255/41/30

Hepatic encephalopathy (none/grade I–II/grade III–IV)

284/31/11

Past history of spontaneous bacterial peritonitis (yes/no)

2/324

Past history of variceal bleeding (yes/no)

3/323

White blood cell (/mm3)

4800 (1100–21,330)

Hemoglobin (g/dL)

11.7 (6.7–18.7)

Platelet (× 103/mm3)

126 (23–549)

PT (%)

80.6 (6.7–173)

Albumin (g/dL)

3.5 (1.5–4.8)

AST (U/L)

37 (3–1177)

ALT (U/L)

25 (2–1509)

Total bilirubin (mg/dL)

1.0 (0.2–29.0)

ALP (U/dL)

391 (75–4600)

γ-GTP (mg/dL)

47 (9–1769)

BUN (mg/dL)

17.0 (4.8–143.2)

Creatinine (mg/dL)

0.84 (0.33–11.7)

eGFR (mL/min/1.73 m2)

61.0 (3.9–140.2)

AFP (ng/mL)

4.3 (0.7–180,434)

M2BPGi (C.O.I.)

2.66 (0.42–18.2)

FIB-4 index

3.84 (0.52–31.0)

ALBI score

− 2.17 (− 3.53 to 0.67)

MELD score

11.1 (6–30)

  1. Data are presented as numbers or medians (ranges).
  2. HCV hepatitis C virus, PBC primary biliary cholangitis, Alc alcoholic hepatitis, NASH non-alcoholic steatohepatitis, HBV hepatitis B virus, AIH autoimmune hepatitis, PT prothrombin time, AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, γ-GTP gamma glutamyl transpeptidase, BUN blood urea nitrogen, eGFR estimated glomerular filtration rate, AFP α-fetoprotein, M2BPGi Mac-2 binding protein glycosylation isomer, FIB-4 fibrosis-4, ALBI score albumin–bilirubin score, MELD score model for end-stage liver disease score.
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