Figure 4 | Scientific Reports

Figure 4

From: Apical-out airway organoids as a platform for studying viral infections and screening for antiviral drugs

Figure 4

Ap-O AO are susceptible to infection with RV-A16, IAV and IBV. Viral load of IAV (A), IBV (B) and RV-A16 (C) detected by qPCR in the supernatant. Apical-out airway organoids show susceptibility to infection with the tested viruses, and can support the generation of high viral titers. Points represent mean values of all biological replicates. Error bars represent the SD (n = 3). (D) CPE following infection with RV-A16, IAV and IBV. Infected Ap-O AO tend to disintegrate to single cells over the course of the infection with the two Influenza viruses. Single organoids can still be observed at 96 hpi with RV-A16 (scale bars = 300 μm).

Back to article page