Table 3 Putative novel drug resistant mutations.
From: Characterisation of drug-resistant Mycobacterium tuberculosis mutations and transmission in Pakistan
Drug | Gene | Change [N] |
|---|---|---|
Amikacin | rrs | −92 T > G [1], 878 g > a [2] |
Ciprofloxacin | gyrA | A288D [1] |
gyrB | −162C > CG [1], A432V [1] | |
Ethambutol | embA | −16C > A [2], −27TA > T [1], −42CAT > C [1], −8C > A [1], P455Q [1], V534A [1] |
embB | R524H [1], D328H [1], D328F [2], L172R [2], F330L [1], T546I [1] | |
ubiA | G268D [1], F238I [1], V188L [1] | |
Isoniazid | ahpC | −52C > A [1], −72C > T [1], −76 T > A [4], −76 T > C [1], −76 T > G [1], −93G > A [1] |
kasA | M72I [1], F402I [1] | |
katG | 587_588insGGT [1], A122D [1], A348G [1], R484G [1], D189Y [1], Q36* [1], G186D [1], G299D [1], I103V [1], L298S [1], M105I [1], F408S [1], P100T [1], T271I [1], T475I [1], T625K [1], W204* [1], W438* [1], Y197D [1] | |
Kanamycin | eis | L386I [1] |
rrs | −92 T > G [1] | |
Pyrazinamide | pncA | −7 T > G [1], 392_393insGGT [1], 451_462del [1], 511_512insTCGCCG [1], L120R [4], P62T [1], P69T [1], S18* [1], V130M [1], V180A [1] |
rpsA | −98A > T [1], Q410R [2] | |
Rifampicin | rpoB | 1291_1292insGCC [1], 1294_1296del [1], 1309_1311del [1] |
Streptomycin | gid | A119D [1], A82P [1], D67G [1], G71* [2] |
