Table 6 Covariates in causal models.

From: Short-term causal effects of common treatments in ambulatory children and young adults with cerebral palsy: three machine learning estimates

Category

Variables

Diagnosis

Topographic sub-type, diagnosis side, whether limb is affected or unaffected (unilateral sub-types)

Anthropometry

Age, sex

Time and distance parameters

Timing of foot-off, opposite foot-off, and opposite foot contact, dimensionless speed and step length (17)

Neurological Impairments

Spasticity: Modified Ashworth Scores for hip adductors, hip flexors, hamstrings, plantarflexors, and rectus femoris

Strength: Manual Muscle Test Grades for hip abductors, hip flexors and extensors, knee flexors and extensors, and plantarflexors

Static selective motor control: Clinical grade of absent, diminished, or typical control for hip abductors, hip flexors, hip extensors, knee flexors, knee extensors, and ankle plantarflexors

Contracture

Ankle: maximum passive ankle dorsiflexion (knee at 0° and 90° of flexion)

Knee: maximum passive knee flexion and extension

Hip: maximum passive hip flexion and extension

Bony alignment

Tibial torsion: bimalleolar axis angle

Femoral anteversion: anteversion estimated by trochanteric prominence test, maximum hip internal and external rotation

Kinematic gait deviations

Gait deviation Index

Discretized kinematic data for Levels × Planes × Measures, where

 levels = pelvis, hip, knee, ankle, and foot

 planes = sagittal, coronal, and transverse plane

 measures = angle value at initial contact and foot-off, angle value and timing of maximum and minimum during stance, swing, and overall, mean angle, angle range of motion during stance, swing, and gait cycle

Mobility-related function

Gross Motor Function Classification System (GMFCS) level

Prior and interval treatment

Neurological: selective dorsal rhizotomy, botulinum toxin type A or phenol injection, intrathecal baclofen pump implantation, other neurosurgery (e.g., shunt placement, neurectomy)

Bony: femoral derotation osteotomy, tibial derotation osteotomy, foot and ankle bony surgery, distal femoral extension osteotomy

Soft tissue: adductor release, foot and ankle soft tissue surgery, calf muscle lengthening, psoas release, hamstrings lengthening, patellar advance, rectus femoris transfer

Casting: lower leg cast (short or long)

Propensity: probability of receiving one of the 13 target treatments