Table 4 Renal and cardiac function comparisons between “Decreasing Hb” group and “Stable Hb” group at baseline and at 6, 12, and 18 months after initiating S/V.

From: Anemia warrants treatment to improve survival in patients with heart failure receiving sacubitril–valsartan

Variables

Timepoint

Decreasing Hb (n = 84)

Stable Hb (n = 110)

p-value

Deaths, n (%)

6

3 (3.8)

0 (0)

0.0458

12

3 (3.8)

2 (1.8)

0.4451

18

7 (8.3)

3 (2.7)

0.0802

21

9 (10.7)

4 (3.6)

0.0793

24

11 (13.1)

4 (3.6)

0.0269

LVEF, mean ± SD

Baseline

30.69 ± 7.610

29.89 ± 7.381

0.4684

6

37.52 ± 10.92

35.30 ± 12.36

0.1529

12

36.44 ± 12.41

37.26 ± 11.78

0.4908

18

37.92 ± 11.85

34.85 ± 11.40

0.2099

NT-proBNP, median (IQR)

Baseline

3754 (1837–6342)

1872 (772–3719)

0.0005

6

1285 (525–3462)

528 (143–1424)

0.0005

12

2200 (471–4218)

489 (112–1721)

0.0004

18

1551 (432–4882)

428 (172–1219)

0.0002

eGFR, mean ± SD

Baseline

69.43 ± 26.25

76.65 ± 23.61

0.0586

6

62.08 ± 25.83

74.12 ± 26.76

0.0051

12

63.81 ± 28.25

74.28 ± 27.57

0.0072

18

61.99 ± 35.10

71.71 ± 29.82

0.0435

BUN, mean ± SD

Baseline

25.50 ± 13.39

22.20 ± 8.64

0.2839

6

26.79 ± 14.20

22.50 ± 10.81

0.0194

12

28.11 ± 13.27

24.02 ± 14.26

0.0139

18

30.22 ± 18.66

24.82 ± 12.84

0.0806

BUN/CRE, mean ± SD

Baseline

21.59 ± 6.87

19.65 ± 5.39

0.0538

6

20.20 ± 6.30

19.40 ± 6.84

0.1448

12

22.41 ± 7.63

19.99 ± 6.41

0.0250

18

23.48 ± 12.30

19.60 ± 6.76

0.0725

Hb, mean ± SD

Baseline

12.7 ± 1.4

15.3 ± 1.2

 < 0.0001

6

12.5 ± 1.4

14.7 ± 1.3

 < 0.0001

12

12.9 ± 1.3

14.6 ± 1.2

 < 0.0001

18

12.0 ± 1.4

14.8 ± 1.0

 < 0.0001

MCV, mean ± SD

Baseline

90.83 ± 6.89

90.74 ± 5.25

0.9158

6

92.99 ± 6.26

92.27 ± 5.97

0.9473

12

93.32 ± 7.57

92.49 ± 5.13

0.3190

18

93.31 ± 7.27

91.97 ± 4.80

0.1219

RDW-CV, mean ± SD

Baseline

15.06 ± 2.63

14.00 ± 1.68

0.0002

6

14.44 ± 2.14

13.62 ± 1.96

0.0037

12

14.33 ± 1.74

13.58 ± 2.04

0.0025

18

14.92 ± 2.56

13.23 ± 0.97

 < 0.0001

  1. BUN blood urea nitrogen, CRE serum creatinine, eGFR estimated glomerular filtration rate, LVEF left ventricular ejection fraction, MCV mean corpuscular volume, NT-proBNP N-terminal pro-B-type natriuretic peptide, RDW-CV red cell distribution width coefficient of variation.
  2. Significant values are in bold.
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