Table 2 Association of genetic loci with log UMCR in a Taiwan Han Chinese population.

From: A genome-wide association study for melatonin secretion

SNP

Chr

Position

Nearest gene

UMCR increasing allele

Other allele

UMCR increasing allele frequency

Model 1

Model 2

P value

Beta (SEM)

P value

Beta (SEM)

rs17681554

16

73,016,768

ZFHX3

A

C

0.804

6.86 × 10−7

0.068 (0.014)

6.83 × 10−7

0.068 (0.014)

rs142037747

3

16,121,712

GALNT15

G

A

0.989

7.82 × 10−7

0.256 (0.052)

7.73 × 10−7

0.256 (0.052)

rs7571016

2

155,166,873

GALNT13

A

G

0.617

1.53 × 10−6

0.056 (0.011)

1.54 × 10−6

0.056 (0.012)

rs9645614

11

36,159,947

LDLRAD3

A

G

0.953

2.90 × 10−6

0.124 (0.026)

2.91 × 10−6

0.124 (0.026)

rs6451653

5

42,915,584

SEPP1-FLJ32255

G

A

0.869

3.44 × 10−6

0.080 (0.017)

3.42 × 10−6

0.080 (0.017)

  1. Model 1 was adjusted for age, sex and the first ten principal components of ancestry.
  2. Model 2 was additionally adjusted for eGFR.
  3. SNP single nucleotide polymorphism, Chr chromosome.
  4. SNPs are imputed with high info score (0.831, 0.988 and 0.946 for rs142037747, rs9645614 and rs6451653, respectively).
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