Table 2 The effects of asthma and its coexisting respiratory comorbidities on mortality in patients with asthma compared with subjects without asthma.

From: Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study

Ā 

Unadjusted model

Model 1

Model 2

All-cause

Respiratory

All-cause

Respiratory

All-cause

Respiratory

HR (95% CI)

HR (95% CI)

aHR (95% CI)

aHR (95% CI)

aHR (95% CI)

aHR (95% CI)

COPD

Control cohort

Reference

Reference

Reference

Reference

Reference

Reference

Asthma cohort without COPD

0.76 (0.72–0.81)

1.21 (1.01–1.44)

0.95 (0.90–1.01)

1.58 (1.32–1.89)

0.94 (0.89–1.00)

1.53 (1.28–1.84)

Asthma cohort with COPD

2.94 (2.75–3.14)

9.31 (7.99–10.85)

1.49 (1.39–1.59)

4.27 (3.66–4.99)

1.46 (1.36–1.56)

3.95 (3.38–4.61)

Pneumonia

Control cohort

Reference

Reference

Reference

Reference

Reference

Reference

Asthma cohort without pneumonia

0.99 (0.94–1.04)

1.97 (1.70–2.29)

1.03 (0.98–1.09)

2.08 (1.79–2.41)

1.02 (0.97–1.08)

1.99 (1.71–2.30)

Asthma cohort with pneumonia

1.92 (1.75–2.09)

5.92 (4.88–7.19)

1.59 (1.46–1.74)

4.72 (3.89–5.73)

1.56 (1.42–1.70)

4.33 (3.57–5.27)

Bronchiectasis

Control cohort

Reference

Reference

Reference

Reference

Reference

Reference

Asthma cohort without bronchiectasis

1.09 (1.03–1.14)

2.32 (2.03–2.65)

1.12 (1.06–1.17)

2.38 (2.08–2.72)

1.10 (1.05–1.16)

2.26 (1.98–2.59)

Asthma cohort with bronchiectasis

2.50 (2.07–3.02)

11.70 (8.47–16.18)

1.43 (1.18–1.73)

6.35 (4.59–8.78)

1.39 (1.15–1.68)

5.74 (4.15–7.95)

Lung cancer

Control cohort

Reference

Reference

Reference

Reference

Reference

Reference

Asthma cohort without lung cancer

1.11 (1.06–1.16)

2.53 (2.22–2.87)

1.12 (1.07–1.18)

2.55 (2.24–2.90)

1.11 (1.05–1.16)

2.41 (2.11–2.74)

Asthma cohort with lung cancer

7.30 (4.60–11.58)

5.34 (0.75–37.94)

4.11 (2.59–6.52)

3.25 (0.46–23.09)

4.07 (2.57–6.46)

3.12 (0.44–22.10)

  1. Data are presented as a ratio (95% CI).
  2. Model 1: age and sex were adjusted; Model 2: age, sex, and type of insurance were adjusted.
  3. HR, hazard ratio; CI, confidence interval; aHR, adjusted HR; COPD, chronic obstructive pulmonary disease.