Table 1 List of proteins that generated the 71 significant urinary peptides identified in this study, along with their Uniprot IDs, gene names, and the number of peptides detected from each protein. Proteins names marked with a * were previously identified as changing in IC/BPS by prior proteomic studies^21,22,23.

Osteopontin*

OSTP

SPP1

9

Uromodulin*

UROM

UMOD

6

Polymeric immunoglobulin receptor

PIGR

PIGR

5

CD99 antigen

CD99

CD99

3

Inter-alpha-trypsin inhibitor heavy chain H4*

ITIH4

ITIH4

3

Secreted and transmembrane protein 1

SCTM1

SECTM1

3

Protein AMBP

AMBP

AMBP

2

Complement C1r subcomponent-like protein

C1RL

C1RL

2

Collagen alpha-1(III) chain

CO3A1

COL3A1

2

Endothelial protein C receptor

EPCR

PROCR

2

Hemoglobin subunit beta

HBB

HBB

2

Insulin

INS

INS

2

Kininogen-1*

KNG1

KNG1

2

Basement membrane-specific heparan sulfate proteoglycan core protein*

PGBM

HSPG2

2

Roundabout homolog 4

ROBO4

ROBO4

2

Alpha-1-acid glycoprotein 1/2*

A1AG1/A1AG2

ORM1/ORM2

1

Alpha-1-antitrypsin

A1AT

SERPINA1

1

Actin, cytoplasmic 1/2

ACTB/ACTG

ACTB/ACTG1

1

Albumin*

ALBU

ALB

1

Collagen alpha-1(I) chain

CO1A1

COL1A1

1

Collagen alpha-1(X) chain

COAA1

COL10A1

1

Collagen alpha-1(XVIII) chain

COIA1

COL18A1

1

Collagen alpha-1(XXII) chain

COMA1

COL22A1

1

Cystatin-A

CYTA

CSTA

1

Fibrinogen beta chain

FIBB

FGB

1

Gelsolin

GELS

GSN

1

Histone H1.2

H12

H1-2

1

Histone H1.4

H14

H1-4

1

Insulin-like growth factor-binding protein 7

IBP7

IGFBP7

1

Insulin-like growth factor II

IGF2

IGF2

1

Immunoglobulin heavy constant gamma 1/2

IGHG1/IGHG2

IGHG1/IGHG2

1

Kallikrein-1

KLK1

KLK1

1

Vesicular integral-membrane protein VIP36

LMAN2

LMAN2

1

Nidogen-1*

NID1

NID1

1

Neuropeptide W precursor

NPW

NPW

1

Phosphoinositide-3-kinase-interacting protein 1

P3IP1

PIK3IP1

1

Extracellular superoxide dismutase [Cu–Zn]

SODE

SOD3

1

Neurosecretory protein VGF

VGF

VGF

1

Xylosyltransferase 1

XYLT1

XYLT1

1