Figure 5 | Scientific Reports

Figure 5

From: AAV2-mediated gene therapy for Bietti crystalline dystrophy provides functional CYP4V2 in multiple relevant cell models

Figure 5

CYP4V2 expression in human RPE from retinal explant ex vivo culture transduced with AAV2. (A) The process of setting up ex vivo cultures of the human retina. Star indicates the 4 mm-diameter circular neural retinas and RPE/choroid trephined from the eye using a Biopsy Punch. (B) Immunohistochemistry showed a relatively stronger expression of CYP4V2 in the human RPE ex vivo culture transduced with AAV2.coCYP4V2 compared with those transduced with AAV2.wtCYP4V2.

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