Figure 3 | Scientific Reports

Figure 3

From: iTRAQ proteomics of sentinel lymph nodes for identification of extracellular matrix proteins to flag metastasis in early breast cancer

Figure 3

Photomicrographs showing sentinel lymph node with metastasis (a–e), sentinel lymph node without metastasis (f–j), and benign breast tumor tissue (k,l) in hematoxylin and eosin stained sections under light microscopy. (1) complete effacement of architecture by a metastatic cancer cells; (2) infilteration by a metastatic cancer cells; (3) presence of tumor cell nests in the sub-capsular area with a part of the lymph node seen at one edge; (4) presence of large area of tumor cell nest replacing the normal lymph node parenchyma; (5) complete effacement of architecture by metastatic cancer cells. (6–10) shows prominent reactive centre without any evidence of tumor cells in the lymph node parenchyma and depicts paracortical expansion with vascular proliferation indicative of reactive lymphadenopathy. (11–12) depicts benign breast lesion consisting of terminal duct lobular units with bi-layered epithelium and a slant inter venium stroma.

Back to article page