Table 3 Intra- and postoperative outcomes according to treatment group.

From: Outcomes of simultaneous laparoscopic, hybrid, and open resection in colorectal cancer with synchronous liver metastases: a propensity score-matched study

 

Before propensity score matching

After propensity score matching

Lap (n = 51)

Hybrid (n = 154)

Open (n = 442)

p value

Lap (n = 42)

Hybrid (n = 81)

p value

Lap (n = 48)

Open (n = 136)

p value

Operating time (min), median (range)

300 (162–670)

363 (90–924)

316 (60–725)

0.001

315 (162–670)

330 (90–679)

0.707

308 (162–670)

279 (82–725)

0.070

EBL (mL), median (range)

300 (20–1500)

400 (50–1500)

400 (10–14,500)

 < 0.001

325 (20–1500)

300 (50–1400)

0.516

300 (20–1500)

350 (30–14,500)

0.063

Transfusion, n (%)

5 (9.8)

12 (7.8)

63 (14.3)

0.094

4 (9.5)

5 (6.2)

0.489

5 (10.4)

19 (14.0)

0.530

Colorectal tumor

          

 p/ypT stage, n (%)

   

 < 0.001

  

0.508

  

0.158

  T1–2

8 (15.7)

8 (5.2)

14 (3.2)

 

5 (11.9)

6 (7.4)

 

5 (10.4)

6 (4.4)

 

  T3–4

43 (84.3)

146 (94.8)

428 (96.8)

 

37 (88.1)

75 (92.6)

 

43 (89.6)

130 (95.6)

 

 p/ypN stage, n (%)

   

0.299

  

0.937

  

0.626

  N0

8 (15.7)

18 (11.7)

75 (17.0)

 

6 (14.3)

12 (14.8)

 

7 (14.6)

24 (17.6)

 

  N1–2

43 (84.3)

136 (88.3)

367 (83.0)

 

36 (85.7)

69 (85.2)

 

41 (85.4)

112 (82.4)

 

Differentiation, n (%)

   

0.271

  

0.307

  

0.224

WD/MD

45 (88.2)

146 (94.8)

412 (93.2)

 

37 (88.1)

76 (93.8)

 

42 (87.5)

127 (93.4)

 

PD/Mucinous/SRC

6 (11.8)

8 (5.2)

30 (6.8)

 

5 (11.9)

5 (6.2)

 

6 (12.5)

9 (6.6)

 

 Liver metastases

          

  Maximal lesion size (cm), median (range)

2.0 (0.5–7.0)

2.0 (0.3–16.1)

2.3 (0.1–15.4)

0.011

2.0 (0.5–7.0)

1.9 (0.3–16.1)

0.669

2.0 (0.5–7.0)

2.0 (0.4–12.0)

0.937

  Positive RM, n (%)

5 (9.8)

27 (17.5)

63 (14.3)

0.280

5 (11.9)

12 (14.8)

0.657

5 (10.4)

11 (8.1)

0.567

  Length of RM (cm), median (range)

0.40 (0–3.5)

0.50 (0–8.5)

0.40 (0–11.0)

0.194

0.4 (0–3.5)

0.6 (0–8.0)

0.252

0.4 (0–3.5)

0.5 (0–9.1)

0.442

 Postop hospital stay (days), median (range)

8 (6–21)

11 (5–51)

12 (5–79)

 < 0.001

8 (6–21)

11 (7–40)

 < 0.001

8 (6–21)

11 (5–79)

 < 0.001

Morbidity*, n (%)

12 (23.5)

48 (31.2)

170 (38.5)

0.046

12 (28.6)

21 (25.9)

0.754

12 (25.0)

46 (33.8)

0.258

 Colorectal morbidity

2 (3.9)

4 (2.6)

10 (2.3)

0.765

2 (4.8)

1 (1.2)

0.268

2 (4.2)

1 (0.7)

0.167

  Anastomotic leakage

2 (3.9)

4 (2.6)

5 (1.1)

0.212

2 (4.8)

1 (1.2)

0.268

2 (4.2)

1 (0.7)

0.167

  Intestinal ischemia

0 (0)

0 (0)

2 (0.5)

0.628

0 (0)

0 (0)

N.A

0 (0)

0 (0)

N.A

  Intestinal stricture

0 (0)

0 (0)

2 (0.5)

0.628

0 (0)

0 (0)

N.A

0 (0)

0 (0)

N.A

  Anastomotic bleeding

0 (0)

0 (0)

1 (0.2)

0.793

0 (0)

0 (0)

N.A

0 (0)

0 (0)

N.A

 Liver morbidity

3 (5.9)

3 (1.9)

17 (3.8)

0.354

3 (7.1)

1 (1.2)

0.115

3 (6.3)

3 (2.2)

0.184

  Biliary collection

3 (5.9)

1 (0.6)

13 (2.9)

0.098

3 (7.1)

0 (0)

0.038

3 (6.3)

3 (2.2)

0.184

  Biliary obstruction

0 (0)

0 (0)

1 (0.2)

0.793

0 (0)

0 (0)

N.A

0 (0)

0 (0)

N.A

  Hepatic bleeding

0 (0)

2 (1.3)

0 (0)

0.040

0 (0)

1 (1.2)

 > 0.999

0 (0)

0 (0)

N.A

  Hepatic failure

0 (0)

0 (0)

3 (0.7)

0.497

0 (0)

0 (0)

N.A

0 (0)

0 (0)

N.A

  Portal vein thrombosis

0 (0)

0 (0)

2 (0.5)

0.628

0 (0)

0 (0)

N.A

0 (0)

0 (0)

N.A

 General morbidity

7 (13.7)

44 (28.6)

144 (32.6)

0.019

7 (16.7)

19 (23.5)

0.382

7 (14.6)

43 (31.6)

0.023

  Wound Cx

1 (2.0)

14 (9.1)

70 (15.8)

0.005

1 (2.4)

8 (9.9)

0.164

1 (2.1)

18 (13.2)

0.028

  Prolonged ileus

1 (2.0)

13 (8.4)

32 (7.2)

0.291

1 (2.4)

5 (6.2)

0.663

1 (2.1)

10 (7.4)

0.293

  Urinary retention

3 (5.9)

16 (10.4)

20 (4.5)

0.031

3 (7.1)

6 (7.4)

 > 0.999

3 (6.3)

7 (5.1)

0.722

  Cardiovascular Cx

0 (0)

0 (0)

3 (0.7)

0.497

0 (0)

0 (0)

N.A

0 (0)

2 (1.5)

 > 0.999

  Pulmonary Cx

2 (3.9)

2 (1.3)

19 (4.3)

0.221

2 (4.8)

0 (0)

0.115

2 (4.2)

6 (4.4)

 > 0.999

  Neuropsychiatric Cx

0 (0)

0 (0)

3 (0.7)

0.497

0 (0)

0 (0)

N.A

0 (0)

1 (0.7)

 > 0.999

 Clavien-Dindo classification, n (%)

   

0.045

  

0.703

  

0.508

  Grade < 3

7 (13.7)

38 (24.7)

108 (24.4)

 

7 (16.7)

15 (18.5)

 

7 (14.6)

29 (21.3)

 

  Grade ≥ 3

5 (9.8)

10 (6.5)

61 (13.8)

 

5 (11.9)

6 (7.4)

 

5 (10.4)

17 (12.5)

 

 Mortality†, n (%)

0 (0)

0 (0)

6 (1.4)

0.246

0 (0)

0 (0)

N.A

0 (0)

1 (0.7)

 > 0.999

  1. Lap, laparoscopic; EBL, estimated blood loss; WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated; SRC, signet ring cell; RM, resection margin; Cx, complication; N.A., not applicable.
  2. *90-day postoperative morbidity.
  3. †90-day postoperative mortality.
Back to article page