Figure 5
Angiotensin II (Ang II) infusion induces aortic dissection in MYH11∆K/+ mice. (A) Pathohistological images of descending aortas from Ang II-treated WT and Myh11∆K/+ mice. Cross-sections were stained with HE, EVG and MT (upper panel). The left part in the panel shows elastic fragmentation and fibrotic tissue deposition in non-dissected regions (scale bars = 50 µm, × 400). (B) Circumference of WT and Myh11∆K/+ ascending thoracic aortas after two weeks of Ang II infusion. WT: n = 14; Myh11∆K/+: n = 9. * p < 0.05, Mann–Whitney U test.
