Figure 5

Effects of ADSCs in cerulein induced pancreatitis in mice. (a) Acute pancreatitis was induced by cerulean administered five times. After 24 h, ADSCs were infused to investigate their therapeutic efficacy. (b,c) Activities of lipase and amylase were significantly decreased after ADSC infusion. (d,e) Inflammatory cytokines (IL-6 and TNF-α) were significantly decreased after ADSC infusion, as detected by ELISA. Edema formation, inflammation infiltration, and necrosis were evaluated by histologic analysis. (f) Representative image of mouse pancreas after H&E staining. (g–i) Histologic changes in pancreas isolated on day 4 after last cerulein injection. Data are represented as the mean ± SEM. * vs. cerulein-only injection group * p < 0.05, ** p < 0.01, *** p < 0.001. ADSC adipose-derived stem cell, MSC mesenchymal stem cell, Con control, FBS fetal bovine serum, SFM serum free media.