Figure 2 | Scientific Reports

Figure 2

From: Remuscularization with triiodothyronine and β1-blocker therapy reverses post-ischemic left ventricular dysfunction and adverse remodeling

Figure 2

M + T3 therapy muscularizes the adult heart and increases LV contractile function. (A) Decay of T3 in the circulation after the end of T3 therapy (2 ng/g body weight, daily for 5 days; i.p.) or vehicle (V) control. Comparisons at each time point were made using an unpaired, 2-sided t-test. n = 5 mice/group. ***P < 0.001. (B) Ventricular CM numbers at 14- and 42-days post-therapy (dpt) with vehicle, T3, metoprolol (M) or M + T3. Comparisons were made using 2-way ANOVA, followed by Sidak’s multiple comparison test. n = 7–9 mice/group. ***P < 0.001 for within group (i.e., at 14 or 42 dpt) comparison. (C–E) Changes in body weight (C), LV mass (D) and LVEF (E) at 0 and 14 dpt with V, T3, M or M + T3. In each case, comparisons between values at 0 and 14 dpt were made using a paired, 2-sided t-test. n = 6 mice/group. ***P < 0.001.

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