Figure 8 | Scientific Reports

Figure 8

From: Remuscularization with triiodothyronine and β1-blocker therapy reverses post-ischemic left ventricular dysfunction and adverse remodeling

Figure 8

M + T3 therapy reverse-remodels the post-MI LV. (A) Illustration showing the LV end-diastolic long- and short-axis dimensions, which were determined using echocardiography. (B) Bar graph showing long-to-short axis ratio before MI surgery (baseline, BL), at 30-days post-MI injury (30 dpi) and at 30-, 90- and 150-days after cessation of M + T3 therapy (days post-therapy, dpt). n = 4 mice per group. Data are shown as individual values and the mean ± SEM. Comparisons were made by two-way ANOVA followed by Sidak's multiple comparisons test. **P < 0.01, ***P < 0.001. (C) LV volumes at end-diastole of untreated MI-injured mice or those given T3 or metoprolol monotherapy or M + T3 therapy. Data from uninjured age-matched control hearts are also shown. Two-way analysis of variance (ANOVA), followed by Sidak's multiple comparisons test. **P < 0.01, ***P < 0.001 comparing the combination therapy group to all other post-MI groups at each assessment period. n = 4 mice per group. Data are shown as individual values and the mean ± SEM.

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